- Amplicephalus simplex, Deltocephalus simplex;Athysanus simplarius Osborn & Ball 1902
- Arcopaginula inflata, Tellina simplex;Tellina listeri;Tellina hippopoidea;Tellina ovata Röding, 1798;Tellina striatula Lamarck, 1818;Tellina inflata Gmelin, 1791
- Chamaecrista nictitans, Sensitive Cassia;Sensitive partridge pea;Cassia nictitans;Chamaecrista chiriquensis;Cassia stenocarpa var stenocarpoides;Cassia simplex;Cassia patellifera;Sensitive-plant
- Chamaecrista nictitans_paraguariensis, Cassia flavicoma var paraguariensis;Cassia pennelliana;Cassia simplex;Chamaecrista simplex
- Cheilolejeunea simplex, Strepsilejeunea simplex
- Chondrosum simplex, Bouteloua simplex
- Dannella simplex, Timpanoga simplex;Ephemerella simplex;Dark slatewinged olive;Bluewinged olive dun;Small bluewinged olive dun
- Hyospathe elegans, Hyospathe maculata;Chamaedorea falcaria;Hyospathe lehmannii;Hyospathe concinna;Hyospathe simplex
- Kyboasca simplex, Empoasca simplex
- Macroclinium simplex, Notylia simplex
- Metzgeria simplex, Metzgeria conjugata subsp simplex
- Plagiochila simplex, Jungermannia simplex;Plagiochila confundens;Plagiochila distinctifolia var latifolia;Plagiochila duriei;Plagiochila erronea
| - Polysporina simplex, Biatorella simplex;Sarcogyne simplex;Biatorella revertens;Lecanora privigna var revertens
- Procloeon simplex, Cloeon simplex
- Reinhardtia simplex, Malortiea simplex
- Sarcoglottis simplex, Veyretia simplex;Spiranthes simplex
- Schistochila balfouriana, Gottschea balfouriana;Gottschea ciliistipula;Gottschea epiphyta;Gottschea laete-virens;Gottschea longiciliata;Gottschea mitteniana;Gottschea moniliformis;Gottschea nitida;Gottschea simplex;Gottschea trichotoma;Gottschea truncatula;Gottschea unguicularis;Jungermannia balfouriana;Jungermannia unguicularis;Schistochila unguicularis
- Siphula ceratites, Siphula simplex
- Speranza simplex, Itame simplex
- Sympistis simplex, Oncocnemis simplex
- Syngonanthus simplex, Syngonanthus eriophyllus;Syngonanthus vareschii;Paepalanthus simplex;Paepalanthus eriophyllus;Paepalanthus filipes
- Syngonanthus umbellatus, Paepalanthus umbellatus;Syngonanthus humboldtii var simplex;Eriocaulon umbellatum;Syngonanthus umbellatus fma proliferens
- Voyria tenella, Puerto Rico ghostplant;Leiphaimos tenella;Leiphaimos obconica;Voyria simplex
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